Targeting cholesterol-dependent Piezo1 activation impairs amoeboid migration in melanoma cells
Proceedings of the National Academy of Sciences, Volume 123, Issue 37, September 2026.
SignificanceThis study builds on a phenotypic drug screen that identified statins as inhibitors of bleb-based migration, a key mode of cancer cell movement through confined spaces. We show that statins reduce membrane cholesterol, disrupting the function ...
SignificanceThis study builds on a phenotypic drug screen that identified statins as inhibitors of bleb-based migration, a key mode of cancer cell movement through confined spaces. We show that statins reduce membrane cholesterol, disrupting the function ...